Unruptured intracranial aneurysms

Transcriptome network-based method to identify genes associated with unruptured intracranial aneurysms

L. Wei, Gao, Y. J., Wei, S. P., Zhang, Y. F., Zhang, W. F., Jiang, J. X., Sun, Z. Y., and Xu, W., Transcriptome network-based method to identify genes associated with unruptured intracranial aneurysms, vol. 12, pp. 3263-3273, 2013.

Intracranial aneurysm is a balloon or sac-like dilatation of blood vessels inside the brain. Despite their importance, the biological mechanisms of intracranial aneurysms are not totally understood. We used public genome-wide gene expression profile data to identify potential genes that are involved in intracranial aneurysm in order to construct a regulation network. Some of the transcription factors and target genes that we identified in this network had been identified as related to intracranial aneurysm in previous studies.

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