Uncoupling protein 1

WY14643 combined with all-trans retinoic acid acts via p38 MAPK to induce “browning” of white adipocytes in mice

J. Wang, Sun, G. J., Ding, J., Zhang, J. X., Cui, Y., Li, H. R., and Wang, S. J., WY14643 combined with all-trans retinoic acid acts via p38 MAPK to induce “browning” of white adipocytes in mice, vol. 14, pp. 6978-6984, 2015.

The ability of mammals to resist body fat accumulation is linked to their ability to expand the number of “brown adipocytes” within white fat depots. All-trans retinoic acid (t-RA) and peroxi­some proliferator-activated receptor-α (PPARα) have been implicated in “browning-like” or “browning” programs, respectively. However, a PPARα-agonist (WY14643) failed to regulate the expression of the uncoupling protein 1(UCP1) gene unless combined with retinoic acid.

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