Ulcerative colitis

Expression and clinical significance of CD4+ CD45+ peripheral blood T cells in patients with ulcerative colitis

L. Y. Guo, Li, Y. R., and Jin, X. P., “Expression and clinical significance of CD4+ CD45+ peripheral blood T cells in patients with ulcerative colitis”, vol. 14, pp. 10338-10343, 2015.

The objectives of this study were to explore the expression of peripheral blood CD4+CD45+ T cells in patients with ulcerative colitis (UC) and determine its clinical value. We selected 80 patients with UC from the First Affiliated Hospital of Liaoning Medical University from March 2012 to December 2013. Of these, 27 had mildly active, 28 moderately active, and 25 severely active UC. We also recruited 80 subjects to constitute the healthy control group.

Effect of curcumin on p38MAPK expression in DSS-induced murine ulcerative colitis

C. - P. Li, Li, J. - H., He, S. - Y., Chen, O., and Shi, L., “Effect of curcumin on p38MAPK expression in DSS-induced murine ulcerative colitis”, vol. 14, pp. 3450-3458, 2015.

The aim of this study was to determine the therapeutic effect of curcumin on dextran sulfate sodium-induced ulcerative colitis (UC) and to explore the related mechanism. Sixty mice were randomly divided into 6 groups. A group was the normal control group; B group was the model group; C group was the 1.5 mg/kg dexamethasone group based on the B group; and D, E and F groups were 15, 30, and 60 mg/kg curcumin groups, respectively, based on the B group.

Association between STAT3 gene polymorphisms and ulcerative colitis susceptibility: a case-control study in the Chinese Han population

L. Wang, Wang, Z. - T., Zhang, H. - X., Liu, J., Lu, S. - Y., Fan, R., Zhou, J., Xia, L., Sun, Y. - W., Zhong, J., and Yuan, Y. - Z., “Association between STAT3 gene polymorphisms and ulcerative colitis susceptibility: a case-control study in the Chinese Han population”, vol. 13, pp. 2343-2348, 2014.

Ulcerative colitis (UC) is a chronic inflammation of the large intestine. The aim of this study was to investigate the association of two polymorphisms in STAT3 with the risk of UC development in the Chinese Han population. This is a hospital-based case-control study involving 56 UC patients and 274 controls. Genotyping was performed using the polymerase chain reaction with sequence-specific primers (PCR-SSP) method. Statistical analyses were conducted using logistic regression and genotype risk score.

Effect of secondary lymphoid tissue chemokine suppression on experimental ulcerative colitis in mice

H. Zhang, Zhang, X., Ding, X., Cao, W., Qu, L., and Zhou, G., “Effect of secondary lymphoid tissue chemokine suppression on experimental ulcerative colitis in mice”, vol. 13, pp. 3337-3345, 2014.

The secondary lymphoid tissue chemokine (CCL21) is closely associated with lymphoid homing and anti-tumor immune responses. CCL21 also has a chemotactic effect on intestinal lymphocytes. This study mainly focused on CCL21 expression in experimental ulcerative colitis and on the effects of CCL21 suppression on this disease in mice. The mouse colitis model was induced by dextran sulfate sodium (DSS) in 40 female BALB/c mice that were equally distributed into five groups: control, DSS, propylene glycol, triptolide (TL), and dexamethasone treatment groups.

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