Effect of secondary lymphoid tissue chemokine suppression on experimental ulcerative colitis in mice
“Effect of secondary lymphoid tissue chemokine suppression on experimental ulcerative colitis in mice”, vol. 13, pp. 3337-3345, 2014.,
The secondary lymphoid tissue chemokine (CCL21) is closely associated with lymphoid homing and anti-tumor immune responses. CCL21 also has a chemotactic effect on intestinal lymphocytes. This study mainly focused on CCL21 expression in experimental ulcerative colitis and on the effects of CCL21 suppression on this disease in mice. The mouse colitis model was induced by dextran sulfate sodium (DSS) in 40 female BALB/c mice that were equally distributed into five groups: control, DSS, propylene glycol, triptolide (TL), and dexamethasone treatment groups.