Type I collagen

Effect of co-culturing human primary basic fibroblasts with respiratory syncytial virus-infected 16-HBE cells

J. - H. Wang, Sun, L. - H., Huang, S. - K., Chen, A. - H., Wang, J. - H., Sun, L. - H., Huang, S. - K., and Chen, A. - H., Effect of co-culturing human primary basic fibroblasts with respiratory syncytial virus-infected 16-HBE cells, vol. 15, p. -, 2016.

This study investigated the effects induced by co-culturing human primary basic fibroblasts (HPBFs) with 16-human bronchial epithelial cells (16-HBE) infected with respiratory syncytial virus (RSV), in particular the transformation of HPBFs into myofibroblasts and secretion of extracellular matrix proteins. HPBFs were co-cultured with 16-HBE cells infected with RSV and quantitatively analyzed. We constructed models of HPBFs co-cultured with 16-HBE cells that were either uninfected (control group) or infected with RSV (experimental group).

Influence of COL1A2 gene variants on the incidence of hypertensive intracerebral hemorrhage in a Chinese population

D. Z. Tian, Wei, W., Dong, Y. J., Tian, D. Z., Wei, W., and Dong, Y. J., Influence of COL1A2 gene variants on the incidence of hypertensive intracerebral hemorrhage in a Chinese population, vol. 15, p. -, 2016.

Type I collagen (transcribed by COL1A1 and COL1A2 genes) is important for maintaining vessel wall elasticity and is a critical part of the extracellular matrix. We conducted a case-control study to investigate the role of the COL1A2 rs42524 polymorphism in the development of hypertensive intracerebral hemorrhage. Between January 2012 and December 2014, a total of 227 patients with hypertensive intracerebral hemorrhage and 227 controls were selected from the Affiliated Hospital of Yanan University (China).

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