Type 2 diabetes mellitus

Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients

F. J. Wei, Cai, C. Y., Yu, P., Lv, J., Ling, C., Shi, W. T., Jiao, H. X., Chang, B. C., Yang, F. H., Tian, Y., Li, M. S., Wang, Y. H., Zou, L., Shi, J. M., Chen, L. M., and Li, W. D., Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients, vol. 14, pp. 15471-15481, 2015.

Recent genome-wide association studies have identified many loci associated with type 2 diabetes mellitus (T2DM), hyperuricemia, and obesity in various ethnic populations. However, quantitative traits have been less well investigated in Han Chinese T2DM populations. We investigated the association between candidate gene single nucleotide polymorphisms (SNPs) and metabolic syndrome-related quantitative traits in Han Chinese T2DM subjects. Unrelated Han Chinese T2DM patients (1975) were recruited.

Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus

J. Wu, Hou, S. S., Wang, W., Yin, M., Cheng, N., Ge, L. L., Yin, J. J., and Xu, J., Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus, vol. 14, pp. 16938-16947, 2015.

The objective of this study was to investigate the mRNA expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) after gastric bypass surgery (GBS) in rats with type 2 diabetic mellitus (T2DM). Thirty-six male Goto-Kakizaki rats, aged 12 weeks, were randomly divided into the GBS, sham operation with diet restriction (SO), and sham operation alone (control) groups (N = 12 per group). Liver specimens from all rats were obtained during the operation and 8 weeks after operation. Blood lipid levels were measured before and 8 weeks after operation.

Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population

Y. Yang, Xu, J. R., Wang, Y. J., and Liu, X. M., Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population, vol. 14, pp. 10064-10071, 2015.

Diabetes is one of costly chronic diseases. Previous studies across several ethnicities have shown that polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene were strongly associated with susceptibility to type 2 diabetes (T2DM). In the present study, the association between the TCF7L2 gene and the susceptibility to T2DM in a Chinese Hui population was interrogated.

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