Type 2 diabetes

Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes

Y. L. Chen, Pei, D., Hung, Y. J., Lee, C. H., Hsiao, F. C., Wu, C. Z., Lin, J. D., Hsu, C. H., Chang, J. B., and Hsieh, C. H., Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes, vol. 14, pp. 2518-2526, 2015.

Metabolic syndrome (MetS) includes obesity, dyslipidemia, elevated blood pressure, and dysglycemia. Subjects with type 2 diabetes (T2D) exhibit features of MetS. The etiology of MetS is complex, involving both environmental and genetic factors. In this study, we examined the role of specific candidate genetic variants on the severity of MetS in T2D subjects. A total of 240 T2D subjects aged 35-64 years were recruited. Waist circumstance, plasma triglycerides, high-density lipoprotein cholesterol, fasting plasma glucose, and blood pressure were measured to define MetS.

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