Type 2 diabetes

High-resolution color doppler ultrasound examination and related risk factor analysis of lower extremity vasculopathy in type 2 diabetes patients

J. Xu, Wang, G., Fu, D., Su, N., Wang, L., Gao, F., and Guo, N., High-resolution color doppler ultrasound examination and related risk factor analysis of lower extremity vasculopathy in type 2 diabetes patients, vol. 14, pp. 3939-3947, 2015.

This study aims to investigate the value of high-resolution color Doppler ultrasonography (HR-CDU) in the evaluation of lower-extremity vasculopathy (LEV) and its related risk factors in type 2 diabetes mellitus (T2DM) patients. Two hundred forty T2DM patients were selected, who underwent lower-extremity arterial HR-CDU. The patients were divided into the LEV group (V group) and the nonvasculopathy group (A group). The V group was then divided into the mild (B group), moderate (C group), and severe (D group) subgroups. The relevant clinical parameters were simultaneously recorded.

Oligonucleotide microarray analysis reveals dysregulation of energy-related metabolism in insulin-sensitive tissues of type 2 diabetes patients

M. Wang, Wang, X. C., Zhao, L., Zhang, Y., Yao, L. L., Lin, Y., Peng, Y. D., and Hu, R. M., Oligonucleotide microarray analysis reveals dysregulation of energy-related metabolism in insulin-sensitive tissues of type 2 diabetes patients, vol. 13, pp. 4494-4504, 2014.

Impaired insulin action within skeletal muscle, adipose tissue, and the liver is an important characteristic of type 2 diabetes (T2D). In order to identify common underlying defects in insulin-sensitive tissues that may be involved in the pathogenesis of T2D, the gene expression profiles of skeletal muscle, visceral adipose tissue, and liver from autopsy donors with or without T2D were examined using oligonucleotide microarrays and quantitative reverse transcriptase-PCR.

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