Type 2 diabetes

Investigation into the association between NLRP3 gene polymorphisms and susceptibility to type 2 diabetes mellitus

S. Wang, Fang, F., Jin, W. B., Wang, X., and Zheng, X. S., Investigation into the association between NLRP3 gene polymorphisms and susceptibility to type 2 diabetes mellitus, vol. 14, pp. 17447-17452, 2015.

We conducted a case-control study to investigate the role of three common polymorphisms (rs10754558, rs7512998, and rs12137901) of the gene NLR family, pyrin domain containing 3 (NLRP3) in the development of type 2 diabetes mellitus (T2DM). Between May 2013 and May 2014, 385 patients with T2DM and 401 control subjects were enrolled in our study. Genotyping of the three NLRP3 polymorphisms of interest was performed by polymerase chain reaction-restriction fragment length polymorphism.

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