Turkish population

Genomic analysis of the interleukin-1β-511 and interleukin-6-174 gene polymorphisms in Turkish patients with epilepsy

İ. Gök, Esen, V., and H. Ozlece, K., Genomic analysis of the interleukin-1β-511 and interleukin-6-174 gene polymorphisms in Turkish patients with epilepsy, vol. 13, pp. 8552-8560, 2014.

In this study, we examined the frequency of polymorphisms in the interleukin (IL) genes IL-1β-511 and IL-6-174 in patients with epilepsy as well as a control group in Kars, Turkey. A total of 100 patients diagnosed with epilepsy and 100 nonepileptic subjects as a control group were examined. Peripheral blood samples were acquired from patients and control subjects for DNA extraction. The target region was amplified using polymerase chain reaction and digested using the restriction enzymes SfaNI and AvaI.

Roles of beta2-adrenergic receptor gene polymorphisms in a Turkish population with obstructive sleep apnea syndrome or obesity

İ. Gök, Çelebi, İ., Hüseyinoğlu, N., and Özic, C., Roles of beta2-adrenergic receptor gene polymorphisms in a Turkish population with obstructive sleep apnea syndrome or obesity, vol. 13, pp. 8511-8518, 2014.

We determined the distribution of the Arg16Gly and Gln27Glu polymorphisms of the beta-2 adrenergic receptor gene (ADRB2) in patients with obstructive sleep apnea syndrome as well as a control group in Northeastern Turkey. A total of 52 patients diagnosed with obstructive sleep apnea in a sleep laboratory and 78 control subjects were examined. Peripheral blood samples were taken from patients diagnosed with obstructive sleep apnea by polysomnography. DNA was extracted from blood samples and amplified using polymerase chain reaction.

Evaluation of whether the ACE gene I/D polymorphism constitutes a risk factor for chronic obstructive pulmonary disease in the Turkish population

C. Ayada, Toru, Ü., Genç, O., Yerlikaya, A., Sahin, S., Turgut, S., and Turgut, G., Evaluation of whether the ACE gene I/D polymorphism constitutes a risk factor for chronic obstructive pulmonary disease in the Turkish population, vol. 13, pp. 10427-10433, 2014.

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow obstruction that occurs as a result of the normal inflammatory process to protect against harmful irritants and chemicals. Another physiological regulatory process, the renin angiotensin system (RAS), plays an important role in the pathology of many diseases. Angiotensin converting enzyme (ACE) is a key enzyme of RAS. We investigated the frequency of the ACE gene I/D polymorphism in patients with COPD in Turkey.

Genotype and allele frequencies of MDR1 gene C1236T polymorphism in a Turkish population

G. Gümüş-Akay, üstemoğlu, A. R., Karadağ, A., Sunguroĝlu, A., and Sunguroĝlu, A., Genotype and allele frequencies of MDR1 gene C1236T polymorphism in a Turkish population, vol. 7, pp. 1193-1199, 2008.

Human P-glycoprotein (P-gp) is encoded by the MDR1 gene, which is located on chromosomal region 7q21 and consists of 28 exons. To date, over 50 single nucleotide polymorphisms (SNPs) have been reported for the MDR1 gene. The effect of these polymorphisms on P-gp function or their clinical impact is in most cases unknown, but some of the SNPs are known to be of functional relevance and can also alter the pharmacokinetics of substrate drugs.

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