Tumor suppressor gene

NPRL2 gene expression in the progression of colon tumors

B. Yogurtcu, Hatemi, I., Aydin, I., and Buyru, N., NPRL2 gene expression in the progression of colon tumors, vol. 11, pp. 4810-4816, 2013.

Genetic and epigenetic factors affecting DNA methylation and gene expression are known to be involved in the development of colon cancer, but the full range of genetic alterations and many key genes involved in the pathogenesis of colon cancer remain to be identified. NPRL2 is a candidate tumor suppressor gene identified in the human chromosome 3p21.3 region. We evaluated the role of this gene in the pathogenesis of colorectal cancer by investigating NPRL2 mRNA expression in 55 matched normal and tumor colon tissue samples using quantitative RT-PCR analysis.

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