Tumor-supplied group of factors

Screening of the residual normal ovarian tissue adjacent to orthotopic epithelial ovarian carcinomas in nude mice

G. H. Zhu, Wang, S. T., Yao, M. Z., Cai, J. H., Chen, C. Y., Yang, Z. X., Hong, L., and Yang, S. Y., Screening of the residual normal ovarian tissue adjacent to orthotopic epithelial ovarian carcinomas in nude mice, vol. 13, pp. 2978-2986, 2014.

The objective of this study was to explore the feasibility and methods of screening the residual normal ovarian tissue adjacent to orthotopic ovarian carcinomas in nude mice. Human epithelial ovarian cancer cells (OVCAR3) were subcutaneously implanted for a tumor source and ovarian orthotopic transplantation. The cancer tissue, proximal paraneoplastic tissue, middle paraneoplastic tissue, remote paraneoplastic tissue, and normal ovarian tissue were removed. CK-7, CA125, p53, survivin, MMP-2, and TIMP-2 expression was detected by reverse transcription polymerase chain reaction.

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