Tumor necrosis factor alpha

Meta-analysis of the correlation between the TNF-α308G/A polymorphism and polycystic ovary syndrome

X. B. Liu, Deng, X. H., Zhou, B., Zhang, L., Niu, X. M., Liu, X. B., Deng, X. H., Zhou, B., Zhang, L., and Niu, X. M., “Meta-analysis of the correlation between the TNF-α308G/A polymorphism and polycystic ovary syndrome”, vol. 15, p. -, 2016.

Previous studies have suggested that the tumor necrosis factor alpha (TNF-α) gene 308G/A polymorphism may be associated with polycystic ovary syndrome (PCOS) risk. However, this relationship is controversial. The present meta-analysis aimed to evaluate the correlation between the TNF-α308G/A polymorphism and susceptibility to PCOS. A systematic electronic search of PubMed and Embase databases was conducted using specific inclusion criteria.

Activity of matrix metalloproteinases 2 and 9 in cultured rabbit corneal epithelium cells stimulated by tumor necrosis factor alpha

Z. - Q. Wu, Zhang, Z. - L., Nie, S. - W., Yuan, J., and Yang, Y. - N., “Activity of matrix metalloproteinases 2 and 9 in cultured rabbit corneal epithelium cells stimulated by tumor necrosis factor alpha”, vol. 14, pp. 6360-6368, 2015.

We studied the activity of matrix metalloproteinases (MMP) 2 and 9 generated by cultured rabbit corneal epithelium cells that had been stimulated with tumor necrosis factor alpha (TNF-α), to investigate the possible regulative mechanisms of MMP-2/9 and their potential effect on corneal inflammatory diseases. The rabbit corneal epithelium cells were cultured in vitro and incubated with different concentrations of TNF-α (0, 1, 10, and 100 ng/mL) for 24 h. The activity of MMP-2/9 was examined using gelatin zymography.

Endothelial cells on the proliferation and expression of intercellular adhesion molecule 1 and interleukin 8 of vascular smooth muscle cells

H. - P. Tang, Sun, L. - X., and Han, W., “Endothelial cells on the proliferation and expression of intercellular adhesion molecule 1 and interleukin 8 of vascular smooth muscle cells”, vol. 12, pp. 4363-4370, 2013.

The aim of this study was to investigate the influence of activated endothelial cells on the proliferation and secretion of vas­cular smooth muscle cells (VSMCs). Cultured lung microvascular endothelial cells were treated with or without tumor necrosis factor alpha (TNF-α; 10 ng/mL) for 6 h, and the supernatant was collected and filtered. The supernatant with TNF-α was called fluid A, and that without TNF-α was called fluid B.

Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women

G. L. Flores-Ramos, A. De Dios, E. -, Puebla-Pérez, A. M., Figuera-Villanueva, L. E., Ramos-Silva, A., Ramírez-Patiño, R., Delgado-Saucedo, J. I., Salas-González, E., Zúñiga-González, G. M., Alonzo-Rojo, A., Gutiérrez-Hurtado, I., and Gallegos-Arreola, M. P., “Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women”, vol. 12, pp. 5680-5693, 2013.

The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with those of 465 Mexican women with breast cancer. The observed genotype frequencies for controls and breast cancer patients were 1 and 14% for AA, 13 and 21% for GA, and 86 and 65% for GG, respectively.

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