Tumor necrosis factor-α

Growth factor progranulin blocks tumor necrosis factor-α-mediated inhibition of osteoblast differentiation

N. Wang, Zhang, J., Yang, J. X., Wang, N., Zhang, J., and Yang, J. X., Growth factor progranulin blocks tumor necrosis factor-α-mediated inhibition of osteoblast differentiation, vol. 15, p. -, 2016.

Tumor necrosis factor-α (TNF-α) stimulates osteoclast differentiation and suppresses osteoblast differentiation, leading to bone loss and decreased bone mass in local inflammation areas in patients with rheumatoid arthritis. The growth factor progranulin (PGRN) is expressed in various types of cells and play crucial roles in the pathogenesis of atherosclerosis and arthritis by blocking TNF-α. Here, we investigated the role of PGRN in blocking TNF-α-mediated inhibition of osteoblast differentiation and the regulatory mechanism.

Thermotherapy-induced reduction in glioma invasiveness is mediated by tumor necrosis factor-alpha

L. J. Qin, Zhang, T., Jia, Y. S., Zhang, Y. B., Zhang, Y. X., and Wang, H. T., Thermotherapy-induced reduction in glioma invasiveness is mediated by tumor necrosis factor-alpha, vol. 14, pp. 11771-11779, 2015.

Thermotherapy has been proven to be effective for the treatment of various tumors, including glioma. We determined whether tumor necrosis factor-alpha (TNF-α) is involved in the regulation of the biological processes of glioma development. Reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemistry were used to investigate the levels of TNF-α mRNA and heat shock factor-1 (HSF1) protein, respectively, in glioma cells. Radioimmunoassay was used to dynamically monitor the contents of TNF-α in the nutrient fluid of C6 cells after thermotherapy treatment.

Association between TNF-αrs1799724 and rs1800629 polymorphisms and the risk of Crohn’s disease

Y. Q. Mao, Dong, S. Q., and Gao, M., Association between TNF-αrs1799724 and rs1800629 polymorphisms and the risk of Crohn’s disease, vol. 14, pp. 15811-15821, 2015.

We investigated the associations between 2 major tumor necrosis factor-α (TNF-α) polymorphisms, rs1799724 C>T and rs1800629 G>A, and the susceptibility to Crohn’s disease (CD) using a meta-analysis framework. The PubMed, EBSCO, Ovid, Wiley, Web of Science, WANFANG, and VIP databases (last updated search in October 2014) were comprehensively searched for relevant published studies.

Meta-analysis of the TNF-α-308G/A polymorphism and vitiligo risk

G. Nie, Qi, J. H., Huang, C. W., Yang, T., Shi, N., and Chen, Y. J., Meta-analysis of the TNF-α-308G/A polymorphism and vitiligo risk, vol. 14, pp. 17296-17304, 2015.

Several case-control studies have been conducted to investigate the association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and vitiligo risk. However, the results of these studies are inconsistent; therefore, we attempted to comprehensively evaluate the association between TNF-α-308G/A polymorphism and vitiligo risk via a meta-analysis. Studies reporting the association between TNF-α-308G/A polymorphism and vitiligo risk were retrieved from PubMed and EmBase databases.

Effects of isoflurane preconditioning in the delayed phase on myocardial tumor necrosis factor alpha levels and caspase-3 protein expression in a rabbit model of ischemia-reperfusion injury

K. Ran, Zou, D. Q., Xiao, Y. Y., Chang, Y. T., Duan, K. M., Ou, Y. W., and Li, Z. J., Effects of isoflurane preconditioning in the delayed phase on myocardial tumor necrosis factor alpha levels and caspase-3 protein expression in a rabbit model of ischemia-reperfusion injury, vol. 14, pp. 7267-7273, 2015.

ABSTRACT. This study aimed to investigate the protective effects and the mechanisms underlying these effects of isoflurane preconditioning in the delayed phase of myocardial ischemia-reperfusion injury. We randomly divided 30 healthy male New Zealand white rabbits into three groups with 10 rabbits in each group as follows: sham operation group (C group), ischemia-reperfusion group (I/R group), and 2.0% isoflurane preconditioning group (S group). Rabbits in the C group received thoracotomy for 160 min.

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