Transporter 1 ATP-binding cassette sub-family B

Association between TAP1 gene polymorphisms and alopecia areata in a Korean population

H. K. Kim, Lee, H., Lew, B. L., Sim, W. Y., Kim, Y. O., Lee, S. W., Lee, S., Cho, I. K., Kwon, J. T., and Kim, H. J., Association between TAP1 gene polymorphisms and alopecia areata in a Korean population, vol. 14, pp. 18820-18827, 2015.

The transporter 1 ATP-binding cassette sub-family B (MDR/TAP) gene (TAP1) is located in the major histocompatibility complex class II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways. Investigation of polymorphisms identified in these loci has revealed an association with several autoimmune disorders. Alopecia areata (AA) is a common autoimmune disease resulting from T cell-induced damage to hair follicles.

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