Transgene expression

Position effect variegation and epigenetic modification of a transgene in a pig model

Z. Yin, Kong, Q. R., Zhao, Z. P., Wu, M. L., Mu, Y. S., Hu, K., and Liu, Z. H., Position effect variegation and epigenetic modification of a transgene in a pig model, vol. 11, pp. 355-369, 2012.

Sequences proximal to transgene integration sites are able to regulate transgene expression, resulting in complex position effect variegation. Position effect variegation can cause differences in epigenetic modifications, such as DNA methylation and histone acetylation. However, it is not known which factor, position effect or epigenetic modification, plays a more important role in the regulation of transgene expression.

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