Transferrin receptor

Regulatory effect of iron regulatory protein-2 on iron metabolism in lung cancer

Z. Cheng, Dai, L. L., Song, Y. N., Kang, Y., Si, J. M., Xia, J., and Liu, Y. F., Regulatory effect of iron regulatory protein-2 on iron metabolism in lung cancer, vol. 13, pp. 5514-5522, 2014.

Iron metabolism plays an important role in the pathogenesis of lung cancer. This study aimed to investigate the effect of gene silencing of iron regulatory protein-2 (IRP2) on mRNA and protein expression of transferrin (Tf), transferrin receptor (TfR), and ferritin (Fn) in A549 lung cancer cells. A549 cells were cultured and divided into a liposome control group, a liposome + oligonucleotide (SCODN) control group, and a Lipofectamine + antisense oligonucleotide (ASODN) group. RT-PCR and Western blotting were used to detect mRNA and protein expression of Tf, TfR, and Fn.

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