Transcriptome network

Transcriptome network-based method to identify genes associated with unruptured intracranial aneurysms

L. Wei, Gao, Y. J., Wei, S. P., Zhang, Y. F., Zhang, W. F., Jiang, J. X., Sun, Z. Y., and Xu, W., Transcriptome network-based method to identify genes associated with unruptured intracranial aneurysms, vol. 12, pp. 3263-3273, 2013.

Intracranial aneurysm is a balloon or sac-like dilatation of blood vessels inside the brain. Despite their importance, the biological mechanisms of intracranial aneurysms are not totally understood. We used public genome-wide gene expression profile data to identify potential genes that are involved in intracranial aneurysm in order to construct a regulation network. Some of the transcription factors and target genes that we identified in this network had been identified as related to intracranial aneurysm in previous studies.

Transcriptome network analysis of potential candidate genes for heart failure

J. Chen, Wang, H. Y., and Zeng, C. Y., Transcriptome network analysis of potential candidate genes for heart failure, vol. 12, pp. 4687-4697, 2013.

The purpose of this study was to examine the hypothesis that a transcriptome network can be developed through a set of transcription factors regulated by the expression of various genes induced by dilated cardiomyopathy can be identified and modulated to respond to heart failure. We searched for significant pathways related to dilated cardiomyopathy using the GSE4172 microarray data to identify potential genes related to heart failure.

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