TRAIL

Expression of TRAIL and its receptor DR5 and their significance in acute leukemia cells

S. M. Chen, Sun, H., Liu, Y. F., Ma, J., Zhang, Q. T., Zhu, J., and Li, T., Expression of TRAIL and its receptor DR5 and their significance in acute leukemia cells, vol. 14, pp. 18562-18568, 2015.

We investigated the roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor death receptor 5 (DR5) in the onset of acute leukemia and changes in their expression during chemotherapy. Bone marrow samples from 16 patients newly diagnosed with acute leukemia were collected before chemotherapy. Bone marrow samples from patients with non-hematologic malignancies served as the control group. Peripheral blood samples of patients with acute leukemia were also collected before chemotherapy and at 1 and 3 days after chemotherapy.

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