Tracheal transplantation

MicroRNA screening and functional study of obliterative bronchiolitis in a rat model simulating lung transplantation

J. Wang, Cao, H., Hong, X., Chen, G. H., Fan, H. M., Li, Q. C., Liu, Z. M., and Li, K. F., MicroRNA screening and functional study of obliterative bronchiolitis in a rat model simulating lung transplantation, vol. 14, pp. 19309-19316, 2015.

The aim of this study was to provide the experimental basis for effective prevention and treatment of obliterative bronchiolitis (OB) by studying the changes on the microRNA (miRNA) expression profile after an orthotopic tracheal transplantation (OTT) simulating lung transplantation (LT). The OTT was performed on inbred rats to establish an OB animal model simulating LT, which was confirmed successful through pathological examination after 4 weeks.

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