TPH2

TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese

X. M. Xu, Ding, M., Pang, H., and Wang, B. J., TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese, vol. 13, pp. 1497-1507, 2014.

In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nucleotide polymorphisms (SNPs) in the regulatory regions of TPH2 gene may affect gene expression and biosynthesis of 5-HT triggering to various neuropsychiatric disorders related to 5-HT dysfunction.

Linkage of schizophrenia with TPH2 and 5-HTR2A gene polymorphisms in the Malay population

S. F. Tee, Chow, T. J., Tang, P. Y., and Loh, H. C., Linkage of schizophrenia with TPH2 and 5-HTR2A gene polymorphisms in the Malay population, vol. 9, pp. 1274-1278, 2010.

The serotoninergic system has been implicated in the etiology of schizophrenia and other behavioral disorders. Association studies have focused on the tryptophan hydroxylase 2 gene (TPH2) and the 5-hydroxytryptamine receptor 2A gene (5-HTR2A). We genotyped two single-nucleotide polymorphisms, A1438G of 5-HTR2A and intronic rs1386494 of TPH2 in the Malay population, using a sample size of 289 schizophrenic patients and 130 healthy controls. We found a significant association of A1438G of 5-HTR2A with schizophrenia in Malays.

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