TP53 gene

Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women

M. P. Gallegos-Arreola, Figuera-Villanueva, L. E., Puebla-Pérez, A. M., Montoya-Fuentes, H., Suarez-Rincon, A. E., and Zúñiga-González, G. M., Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women, vol. 11, pp. 1401-1408, 2012.

The TP53 tumor suppressor gene plays an important role in cell cycle regulation; polymorphisms of this gene have been associated with endometriosis. We examined the role of TP53 codon 72 polymorphism by comparing genotypes of 235 healthy Mexican women (controls with surgically excluded endometriosis) with the genotypes of 151 Mexican women with endometriosis. The observed genotype frequencies for controls and endometriosis patients were 8 and 22% for proline/proline (Pro/Pro), 30 and 34% for proline/arginine (Pro/Arg), and 62 and 44% for arginine/arginine (Arg/Arg), respectively.

Numerical aberrations of chromosome 17 and TP53 in brain metastases derived from breast cancer

D. S. Vasconcelos, da Silva, F. P. E., Quintana, L. G., Anselmo, N. P., Othman, M. A. K., Liehr, T., and de Oliveira, E. H. C., Numerical aberrations of chromosome 17 and TP53 in brain metastases derived from breast cancer, vol. 12, pp. 2594-2600, 2013.

Breast cancer is the second most common origin of brain metastases, after lung cancer, and represents 14-20% of all cases. Abnormalities of chromosome 17 are important molecular genetic events in human breast cancer, and several oncogenes and tumor suppressor genes are located on this chromosome. In about half of all human cancers, the tumor suppressor gene TP53, located at 17p13.1, is either lost or mutated.

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