TNF-RII

Sequence analysis of the regulatory region of the TNF-RII gene in Polish Holstein-Friesian cows

A. Stachura, Kaczmarczyk, E., and Bojarojć-Nosowicz, B., Sequence analysis of the regulatory region of the TNF-RII gene in Polish Holstein-Friesian cows, vol. 12. pp. 1028-1034, 2013.

Tumor necrosis factor receptor type II (TNF-RII) is a surface glycoprotein that can form a complex with TNF-α and participate in the body's immune response. Functions of TNF-RII are impaired in the pathogenesis of viral diseases. We analyzed sequences in the regulatory region of the TNF-RII gene in cattle. An attempt was also made to identify mutations that would have the greatest effect on the expression of the TNF-RII gene. Selected fragments of the regulatory region of the TNF-RII gene (5'-flanking region, fragments of intron 1 and 3'-UTR) were sequenced and analyzed.

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