TNF-α

TNF-αG-308A polymorphism is associated with insulin resistance: a meta-analysis

H. G. Wang, Yang, J., Han, H., Xu, F., Bian, Y., Zhang, H., and Wang, J. L., “TNF-αG-308A polymorphism is associated with insulin resistance: a meta-analysis”, vol. 14, pp. 563-573, 2015.

Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conf‍‍licting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE and EMBASE).

Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors

B. X. Ren, Ji, Y., Tang, J. C., Sun, D. P., Hui, X., Yang, D. Q., and Zhu, X. L., “Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors”, vol. 14, pp. 2133-2138, 2015.

The study aimed to investigate the effect of intrathecal injections of Tanshinone IIA on thermal hyperalgesia in a mouse model of bone cancer-pain. Spinal IL-1β, IL-6, TNF-α expression levels were analyzed. C3H/HeNCrlVr male mice were assigned to groups that either received dose-dependent injections of Tanshinone IIA, or the DMSO + Sham, Tanshinone IIA + Sham, DMSO + Tumor, and Control groups. Paw withdrawal thermal latency (PWTL) was measured with a radiant heat stimulus and mRNA expression levels were determined using real-time PCR.

TNF-α -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis

Y. H. Lee and Song, G. G., “TNF-α -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis”, vol. 14, pp. 4966-4977, 2015.

The purpose of this study was to examine whether tu­mor necrosis factor-α (TNF-α) -308 A/G and -238 A/G polymorphisms confer susceptibility to glaucoma. A meta-analysis was conducted ex­amining the association between TNF-α -308 A/G and -238 A/G poly­morphisms and glaucoma. A total of 13 studies on TNF-α -308 A/G and 238 A/G polymorphisms were included in this meta-analysis. The meta-analysis revealed no association between the TNF-α -308 A al­lele and glaucoma [odds ratio (OR) = 1.403, 95% confidence inter­val (CI) = 0.784-2.513, P = 0.254].

Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-α

T. Yu, Lu, Q., Ou, X. L., Cao, D. Z., and Yu, Q., “Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-α”, vol. 13, pp. 10909-10912, 2014.

TNF 308 gene polymorphism and IL-10 polymorphism provided evidence in diagnosing some types of cancer. We aimed to explore the relation of gene polymorphism with gastric cancer. A total of 360 cases of gastric cancer patients were included in the study. The genotypes GG, GA, and AA of the interleukin-10-1082 gene (IL-10-1082) and the tumor necrosis factor-alpha gene (TNF-α) 308 polymorphism were examined by chromogenic detection. Three hundred healthy individuals’ gene as control group were also examined.

Inhibitory effect of alternatively spliced RAGEv1 on the expression of NF-kB and TNF-α in hepatocellular carcinoma cells

T. Lertwittayapon, Tencomnao, T., and Santiyanont, R., “Inhibitory effect of alternatively spliced RAGEv1 on the expression of NF-kB and TNF-α in hepatocellular carcinoma cells”, vol. 11, pp. 1712-1720, 2012.

Binding of specific ligands to the receptor for advanced glycation end-products (RAGE) can trigger a series of signal transductions, which leads to pathogenesis in many chronic degenerative diseases, including cancer. Alternative splicing of RAGE mRNA has resulted in many variants, including RAGE variant 1 (RAGEv1). This particular splice variant of RAGE can provide a major soluble form of RAGE in blood circulation, which can neutralize deleterious ligands, thus diminishing signaling that can lead to inflammation and pathogenesis in cancer cells.

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