TLR4 gene

Sequence characterization and phylogenetic analysis of toll-like receptor (TLR) 4 gene in the Tibetan macaque (Macaca thibetana)

Q. X. Dai, Yao, Y. F., Qi, Z. C., Huang, Y., Ni, Q. Y., Zhang, M. W., and Xu, H. L., Sequence characterization and phylogenetic analysis of toll-like receptor (TLR) 4 gene in the Tibetan macaque (Macaca thibetana), vol. 14, pp. 1875-1886, 2015.

In this study, the complete coding region sequence of an innate immune-related TLR4 gene was obtained from the Tibetan macaque (Macaca thibetana) genome via PCR and direct sequencing. The sequence had a total length of 2481 bp, contained 3 complete exons, and encoded 826 amino acids (AAs); its isoelectric point was 5.703, and the molecular weight was 94.72 kDa. The high structure prediction showed that the protein was comprised of one extracellular region, one transmembrane region, and one intracellular region.

Association of bovine Toll-like receptor 4 with tick infestation rates and blood histamine concentration

G. Zhao, Yu, M., Cui, Q. - W., Zhou, X., Zhang, J. - C., Li, H. - X., Qu, K. - X., Wang, G. - L., and Huang, B. - Z., Association of bovine Toll-like receptor 4 with tick infestation rates and blood histamine concentration, vol. 12, pp. 2783-2793, 2013.

We investigated a possible association between bovine Toll-like receptor 4 (TLR4) and resistance to tick infestation in 103 cattle, including BMY cattle (1/2 Brahman, 1/4 Murray Grey, and 1/4 Yunnan Yellow cattle), Brahman, and Red Angus grazing on improved pasture. The tick infestation weight and number of Rhipicephalus microplus and the blood histamine concentration were measured and compared with those of 32 Chinese Holsteins and 30 Simmentals. A 228-bp fragment was amplified and sequenced to analyze the polymorphisms of the TLR4 gene.

TLR4 gene expression in pig populations and its association with resistance to Escherichia coli F18

J. Wang, Pan, Z. Y., Zheng, X. R., Wu, Z. C., Su, X. M., Zhu, G. Q., Huang, X. G., Wu, S. L., and Bao, W. B., TLR4 gene expression in pig populations and its association with resistance to Escherichia coli F18, vol. 12, pp. 2625-2632, 2013.

TLR4 is the main recognition receptor of bacterial lipopolysaccharides, which play an important role in innate and adaptive immunity. We used real-time PCR to analyze the tissue expression profile and differential expression of TLR4 in 4 pig populations (Escherichia coli F18-resistant Sutai, E. coli F18-sensitive Sutai, Large White, Meishan), in order to determine the role that the TLR4 gene plays in resistance to E. coli F18.

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