Thermo tolerance

A SNP in the 3'-UTR of HSF1 in dairy cattle affects binding of target bta-miR-484

Q. L. Li, Zhang, Z. F., Xia, P., Wang, Y. J., Wu, Z. Y., Jia, Y. H., Chang, S. M., and Chu, M. X., A SNP in the 3'-UTR of HSF1 in dairy cattle affects binding of target bta-miR-484, vol. 14, pp. 12746-12755, 2015.

The heat shock transcription factor 1 gene (HSF1) plays a key role in the heat stress response. We previously found a single nucleotide polymorphism (SNP) in the 3'-untranslated region (g.4693G>T) of HSF1 that was related to thermo tolerance in Chinese Holstein cattle through association analysis. However, it is not known whether other SNPs also affect thermo tolerance.In this study a novel SNP, g.1451G>T, was identified by DNA sequencing and genotyped using creating restriction site-polymerase chain reaction methodology.

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