Teratozoospermia

Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a Brazilian population

W. E. J. C. Mesquita, Approbato, M. S., Moura, K. K. V. O., and Jesuíno, R. S. A., Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a Brazilian population, vol. 8. pp. 1423-1426, 2009.

The androgen receptor (AR) is a protein encoded by the AR gene, which when mutated may affect spermatogenesis, the process in which spermatozoa are produced; thus, AR mutations could lead to male infertility. We examined exon 1 of the AR gene in men with idiopathic infertility. Blood or semen samples from 111 infertile, oligozoospermic (N = 31), asthenozoospermic (N = 23), teratozoospermic (N = 33), and azoospermic (N = 24) men were analyzed. The extracted DNA was amplified for the exon 1 region of the AR gene.

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