Teratogenicity

6-Dimethylaminopurine and cyclohexamide are mutagenic and alter reproductive performance and intrauterine development in vivo

R. J. Oliveira, Mantovani, M. S., Pesarini, J. R., Mauro, M. O., da Silva, A. F., Souza, T. R., and Ribeiro, L. R., 6-Dimethylaminopurine and cyclohexamide are mutagenic and alter reproductive performance and intrauterine development in vivo, vol. 14, pp. 834-849, 2015.

The compounds 6-dimethylaminopurine (6-DMAP) and cyclohexamide (CHX) are currently used to stimulate the development of embryos produced by nuclear transfer in the production of cloned mammals with a great deal success. This study investigated the effects of 6-DMAP and CHX in vivo using biological assays to evaluate reproductive performance in females, teratogenesis, and mutagenesis.

Evaluation of mutagenic, teratogenic, and immunomodulatory effects of Annona nutans hydromethanolic fraction on pregnant mice

C. A. Gonçalves, Silva, N. L., Mauro, M. O., David, N., Cunha-Laura, A. L., Auharek, S. A., Monreal, A. C. D., Vieira, M. C., Silva, D. B., Santos, F. J. L., Siqueira, J. M., and Oliveira, R. J., Evaluation of mutagenic, teratogenic, and immunomodulatory effects of Annona nutans hydromethanolic fraction on pregnant mice, vol. 13, pp. 4392-4405, 2014.

Plants such as Annona nutans used in folk medicine have a large number of biologically active compounds with pharmacological and/or toxic potential. Moreover, pregnant women use these plants indiscriminately, mainly in the form of teas, without being aware of the harm that they could cause to the health of the embryo/fetus. Therefore, it is necessary to analyze the potential toxic effects of medicinal plants during gestation. The present study aimed to evaluate the effects of A.

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