Teratogenesis

Effects of phenylalanine on reproductive performance and teratogenesis in mice

R. J. Oliveira, Pesarini, J. R., Mauro, M. O., Fronza, L. S., Victorelli, S. G., Cantero, W. B., Sena, M. C., and Antoniolli, A. C. M. B., Effects of phenylalanine on reproductive performance and teratogenesis in mice, vol. 13, pp. 5606-5616, 2014.

We evaluated the effects of phenylalanine on reproductive performance and teratogenesis in mice, as well as we assessed its protective effect in mice treated with an acute dose of cyclophosphamide. Animals were divided into 6 experimental groups (females N = 15/group, males N = 5/group): G1, the negative control group, phosphate-buffered saline; G2, the positive control group, 35 mg cyclophosphamide/kg body weight (b.w.); G3 and G4 received phenylalanine at doses of 150 and 300 mg/ kg b.w., respectively; G5 and G6 received phenylalanine at doses of 150 and 300 mg/kg b.w.

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