Systemic lupus erythematosus

Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus

J. R. Lin, Qin, H. H., Wang, Y., Liang, J., Xu, J. H., Lin, J. R., Qin, H. H., Wang, Y., Liang, J., and Xu, J. H., “Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus”, vol. 15, p. -, 2016.

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and diminishes a patients’ quality of life. It has been suggested that interleukin 19 (IL-19) is engaged in intercellular signal transduction, which is related to the immune response and the local inflammatory reaction. Single nucleotide polymorphisms (SNPs) have been used to explore the genetic basis underlying the pathogenesis of SLE. In this study, we investigated the potential correlation between the functional IL19 SNP rs2243188 and SLE.

Vulnerability of atherosclerotic plaques is as­sociated with type I interferon in a murine model of lupus and atherosclerosis

C. Y. Zhang, Qu, B., Ye, P., Li, J., and Bao, C. D., “Vulnerability of atherosclerotic plaques is as­sociated with type I interferon in a murine model of lupus and atherosclerosis”, vol. 14, pp. 14871-14881, 2015.

This study aimed to investigate the relationship between type I interferon (IFN-I) and plaque stability in pristane-treated apolipoprotein E-knockout (ApoE-/-) mice. Antinuclear antibody (ANA) and extractable nuclear antigen antibody (ENA) levels were measured by immunofluorescence and enzyme-linked immunospot assay. Atherosclerotic plaques were detected by Sirius red/fast green staining. Cell apoptosis was detected by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick-end labeling. Gene expression was determined by real-time PCR analyses.

Association between PDCD1, CTLA4, and MECP2 gene polymorphisms and systemic lupus erythematosus in the Chinese Northern Han

H. R. Dong, Li, H. S., Wang, S. C., Balin, Q. M., and Chang, P. Y., “Association between PDCD1, CTLA4, and MECP2 gene polymorphisms and systemic lupus erythematosus in the Chinese Northern Han”, vol. 14, pp. 17567-17573, 2015.

Systemic lupus erythematosus (SLE) is an autoimmune disease that results in chronic inflammation of different organ systems. Several susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes has yet to be determined. The programmed cell death 1 gene (PDCD1), the cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene, and the methyl-CpG-binding protein 2 gene (MECP2) are considered to be the candidate genes associated with SLE.

Association between IL-21 polymorphism and systemic lupus erythematosus: a meta-analysis

J. H. Qi, Qi, J., Xiang, L. N., and Nie, G., “Association between IL-21 polymorphism and systemic lupus erythematosus: a meta-analysis”, vol. 14, pp. 9595-9603, 2015.

Several case-control studies have been conducted to investigate the association between Interleukin-21 (IL-21) polymorphisms and systemic lupus erythematosus (SLE) susceptibility, and most of the studies focused on IL-21 rs907715 and rs2221903 polymorphisms. Given the inconsistent results from these studies, the present meta-analysis aimed to obtain a more precise estimate of the association between IL-21 rs907715 and rs2221903 polymorphisms and SLE. Studies regarding these specific polymorphisms and SLE were retrieved from PubMed, Embase, Web of Science, CNKI, and CBM.

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