System dynamics model

Genetic analysis of differentiation of T-helper lymphocytes

Q. Wang, Li, M., Xia, L. C., Wen, G., Zu, H., and Gao, M., Genetic analysis of differentiation of T-helper lymphocytes, vol. 12, pp. 972-987, 2013.

In the human immune system, T-helper cells are able to differentiate into two lymphocyte subsets: Th1 and Th2. The intracellular signaling pathways of differentiation form a dynamic regulation network by secreting distinctive types of cytokines, while differentiation is regulated by two major gene loci: T-bet and GATA-3. We developed a system dynamics model to simulate the differentiation and re-differentiation process of T-helper cells, based on gene expression levels of T-bet and GATA-3 during differentiation of these cells.

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