Survivin

Role of survivin in the pathogenesis of papillary thyroid carcinoma

J. Y. Li, Shi, J., Sang, J. F., Yao, Y. Z., Wang, X. C., and Su, L., Role of survivin in the pathogenesis of papillary thyroid carcinoma, vol. 14, pp. 15102-15111, 2015.

The purpose of this study was to assess the correlation between the survivin gene and the occurrence and pathogenesis of papillary thyroid carcinoma (PTC). Sixty patients with PTC and no preoperative chemotherapy were recruited for the study and 30 thyrophyma patients receiving operative treatment in Drum Tower Hospital (Nanjing, China) were included as the control group. The protein expression levels of survivin were assessed by immunoblotting and immunohistochemical analysis of tissues from both patient groups.

Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis

X. L. Zhou and Wang, M., Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis, vol. 14, pp. 17059-17067, 2015.

Cervical cancer is associated with abnormal expression of multiple genes. Survivin and Bcl-2 proteins are apoptosis inhibitors. The tumor suppressor gene CD82, which encodes the protein KAI1, is downregulated in cervical cancer, and is associated with differentiation degree. We investigated the expression levels of three proteins and their correlation with metastasis in cervical cancer by comparing them in different cervical lesions.

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