Survivin

Inhibitory effect of survivin-targeting small interfering RNA on gastric cancer cells

Y. H. Li, Chen, M., Zhang, M., Zhang, X. Q., Zhang, S., Yu, C. G., Xu, Z. M., and Zou, X. P., “Inhibitory effect of survivin-targeting small interfering RNA on gastric cancer cells”, vol. 13, pp. 6786-6803, 2014.

A pair of inverted repeated sequences of the gene survivin was designed for stable double-stranded RNA establishment. After stable transfection, the biological behaviors of gastric cancer cells were observed. The interference rates of survivin-targeting siRNA (siRNA-survivin) in BGC823, MKN45, SGC7901, and cisplatin-resistant SGC7901 groups were 55.363 ± 3.974, 71.433 ± 3.774, 69.433 ± 7.336, and 76.767 ± 3.541%, respectively, compared with those in the control group.

Correlation of tumor relapse and elevated expression of survivin and vascular endothelial growth factor in superficial bladder transitional cell carcinoma

Y. W. Sun, Xuan, Q., Shu, Q. A., Wu, S. S., Chen, H., Xiao, J., Xiang, P., Zhu, Y. P., Wang, F. L., and Zhao, S. T., “Correlation of tumor relapse and elevated expression of survivin and vascular endothelial growth factor in superficial bladder transitional cell carcinoma”, vol. 12, pp. 1045-1053, 2013.

Survivin and vascular endothelial growth factor (VEGF) are newly discovered tumor markers closely correlated with bladder cancer. We analyzed the expression of survivin and VEGF in paraffin-embedded tumor tissues from 78 patients with bladder transitional cell carcinoma (BTCC) using an immunohistochemistry method. Normal bladder mucosae from 10 non-BTCC cases were also included as a control group. All patients were closely followed up for tumor recurrence after undergoing transurethral resection of bladder tumor procedures.

Association between survivin gene promoter -31G/C and -644C/T polymorphisms and non-small cell lung cancer

E. Aynaci, Coskunpinar, E., Eren, A., Kum, O., Oltulu, Y. M., Akkaya, N., Turna, A., Yaylim, I., and Yildiz, P., “Association between survivin gene promoter -31G/C and -644C/T polymorphisms and non-small cell lung cancer”, vol. 12, pp. 3975-3982, 2013.

Lung cancer is the most common cancer worldwide. Survivin is one of the first reported inhibitors of apoptosis proteins, which is an important family of proteins that regulate apoptosis. The survivin gene is located on human chromosome 17q25, which is composed of 142 amino acids. A common polymorphism of the survivin gene promoter -31G/C has been shown to influence cancer risk. This genetic variant has been associated with overexpression of survivin at both protein and mRNA levels in cancer cells.

Subscribe to Survivin