Suberanilohydroxamic acid

SAHA attenuates sevoflurane-induced learning and memory impairments in fetal mice

X. F. Lin, Han, Y. Q., Li, H. L., Zhao, Y. P., Fei, X. J., Sheng, J. X., Lu, H. H., Liu, S., and Zhang, L., SAHA attenuates sevoflurane-induced learning and memory impairments in fetal mice, vol. 13, pp. 10769-10778, 2014.

Previous studies have found that children with multiple exposures to anesthesia at an early age are at increased risk of learning and memory impairment. Sevoflurane is the most commonly used inhalational anesthetic for general anesthesia in children. Multiple exposures to sevoflurane have been shown to induce neuroinflammation, inhibit neurogenesis, and cause subsequent learning and memory impairments in fetal mice. Histone-tail acetylation has been implicated in memory formation.

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