Stromal antigen 2

Loss of STAG2 causes aneuploidy in normal human bladder cells

X. Li, Zhang, T. W., Tang, J. L., Fa, P. P., Lu, J. X., Qi, F. M., Cai, Z. M., Liu, C. X., and Sun, X. J., “Loss of STAG2 causes aneuploidy in normal human bladder cells”, vol. 14, pp. 2638-2646, 2015.

The aim of this study was to determine how the function of human stromal antigen 2 (STAG2) plays an important role in proper chromosome separation. STAG2 mRNA in normal bladder cells and bladder tumor cells was evaluated by RT-PCR. The protein levels of STAG2 in normal bladder cells and bladder tumor cells were determined by western blot. A cell proliferation assay was used to measure the growth of tumor cells and STAG2-inhibited normal cells, and STAG2- inhibited normal cells were subjected to karyotype analysis.

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