Stroke

Serotonin receptor 2C gene polymorphism associated with post-stroke depression in Chinese patients

W. K. Tang, Tang, N., Liao, C. D., Liang, H. J., Mok, V. C. T., Ungvari, G. S., and Wong, K. S., “Serotonin receptor 2C gene polymorphism associated with post-stroke depression in Chinese patients”, vol. 12, pp. 1546-1553, 2013.

The serotonin receptor 2C (HTR2C) gene has been shown to play a pivotal role in major depression. We examined the association between post-stroke depression (PSD) and polymorphism in HTR2C. A cohort of 223 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months after the onset of the index stroke, a research assistant administered the locally validated 15-item Geriatric Depression Scale. PSD was defined as a geriatric depression scale score of 7 or above.

Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with stroke risk based on a meta-analysis

Q. Q. Lv, Lu, J., Wu, W., Sun, H., and Zhang, J. S., “Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with stroke risk based on a meta-analysis”, vol. 12, pp. 6882-6894, 2013.

Several independent studies have reported the role of the methylenetetrahydrofolate reductase gene (MTHFR) A1298C polymorphism in strokes, but the results are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed in the present study. In this meta-analysis, a total of 13 studies, including 1974 cases and 2660 controls, were selected to evaluate the possible association. Crude odds ratios (ORs) with 95% confidence intervals (CI) were used to assess the strength of the association in additive, dominant, and recessive models.

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