Expression of neurotrophin-4/5 in Streptococcus pneumoniae meningitis
, “Expression of neurotrophin-4/5 in Streptococcus pneumoniae meningitis”, vol. 13, pp. 2994-3001, 2014.
This study aims to investigate the expression of neurotrophin-4/5 (NT-4/5) in the pallium and hippocampus in juvenile rats with intraventricular injection of Streptococcus pneumoniae. We used 40 SPF SD rats (3 weeks old, regardless of gender) in this study. We drew 50 μL cerebrospinal fluid, and then, we injected 50 μL normal saline and S. pneumoniae suspension (108 CFU/mL) in the brain pool (normal control group and infection group, respectively). After 24 h, the cerebrospinal fluid was collected for bacterial culture and white blood cell count.
