Sexual dimorphism of STGC3 tumor suppressor function in nasopharyngeal carcinoma CNE2 cells
“Sexual dimorphism of STGC3 tumor suppressor function in nasopharyngeal carcinoma CNE2 cells”, vol. 11, pp. 4585-4597, 2012.
, STGC3 is a potential tumor suppressor in nasopharyngeal carcinoma. We previously found that CNE2 cells that re-expressed STGC3 formed smaller tumors in female mice than in male mice. Here, we investigated the sexual dimorphism of STGC3 as a tumor-suppressor in female and male nude mice injected subcutaneously with pcDNA3.1(+)-STGC3/CNE2 cells. ER-α was positively expressed in vitro in the CNE2 cells. The pcDNA3.1(+)-STGC3/CNE2 cell growth rate decreased after treatment with β-estradiol in vitro.