STAT6

Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions

M. Jargosch, Kröger, S., Gralinska, E., Klotz, U., Fang, Z., Chen, W., Leser, U., Selbig, J., Groth, D., Baumgrass, R., Jargosch, M., Kröger, S., Gralinska, E., Klotz, U., Fang, Z., Chen, W., Leser, U., Selbig, J., Groth, D., and Baumgrass, R., Data integration for identification of important transcription factors of STAT6-mediated cell fate decisions, vol. 15, p. -, 2016.

Data integration has become a useful strategy for uncovering new insights into complex biological networks. We studied whether this approach can help to delineate the signal transducer and activator of transcription 6 (STAT6)-mediated transcriptional network driving T helper (Th) 2 cell fate decisions. To this end, we performed an integrative analysis of publicly available RNA-seq data of Stat6-knockout mouse studies together with STAT6 ChIP-seq data and our own gene expression time series data during Th2 cell differentiation.

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