Squamous cell carcinoma

Expression and clinical implications of enhancer of Zeste homolog 2 and p53 protein in squamous cell carcinoma and precancerous lesions in the cervix

H. M. Zhang, Chen, S. Q., Yao, S. Z., Zhang, H. M., Chen, S. Q., and Yao, S. Z., Expression and clinical implications of enhancer of Zeste homolog 2 and p53 protein in squamous cell carcinoma and precancerous lesions in the cervix, vol. 15, p. -, 2016.

We investigated the expression and clinical implications of enhancer of Zeste homolog 2 (EZH2) and p53 protein in cervical squamous cell carcinoma (SCC) and precancerous lesions. EZH2 and p53 expressions in SCC (168), cervical intraepithelial neoplasia (CIN)-I (19), CIN-II (35), and normal tissues (30) were detected by streptavidin-peroxidase-conjugation. The correlation between co-expression of EZH2 and p53 protein and the clinic pathological features and prognosis of SCC were discussed.

Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells

D. X. Li, Zhang, J., Zhang, Y., Zhao, P. W., and Yang, L. M., Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells, vol. 14, pp. 10553-10568, 2015.

Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells.

Roles of the AIB1 protein in the proliferation and transformation of human esophageal squamous cell carcinoma

L. Li, Wei, P., Zhang, M. - H., Zhang, W., Ma, Y., Fang, X., Hao, C. - L., and Zhang, Z. - H., Roles of the AIB1 protein in the proliferation and transformation of human esophageal squamous cell carcinoma, vol. 14, pp. 10376-10383, 2015.

The aim of this study was to investigate the expression of AIB1 in human esophageal squamous cell carcinoma and its correlation with Ki67 expression. The immunohistochemical method streptavidin-perosidase was used to analyze the expression of AIB1 and Ki67 in specimens from 60 patients with esophageal squamous cell carcinoma and in 20 control individuals with normal esophageal tissue. Expression correlation, clinical significance, and relationships between the two groups were determined.

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