Spontaneous abortion

Result and pedigree analysis of spontaneously abortion villus chromosome detecting by FISH

N. An, Li, L. - L., Zhang, X. - Y., Sun, W. - T., Liu, M. - H., and Liu, R. - Z., Result and pedigree analysis of spontaneously abortion villus chromosome detecting by FISH, vol. 14, pp. 16662-16666, 2015.

The aim of this study was to evaluate the relationship between fetal karyotype and parental chromosomal abnormalities, and to provide a basis for clinical diagnosis and therapy in Northeast China. A total of 144 spontaneously aborted fetuses were analyzed by FISH to test for chromosome number and to recall couples for peripheral blood karyotype analysis. The rate of abnormal chorionic villus chromosomes was 35.42%. Villus chromosome abnormality rate of the first spontaneous abortion and repeated abortions were 40.54 and 33.64%, respectively (P < 0.05).

A small supernumerary marker chromosome, derived from chromosome 22, possibly associated with repeated spontaneous abortions

M. Balkan, İsi, H., İsi, H., Gedik, A., Erdemoğlu, M., and Budak, T., A small supernumerary marker chromosome, derived from chromosome 22, possibly associated with repeated spontaneous abortions, vol. 9. pp. 1683-1689, 2010.

We report a phenotypically normal couple with repeated spontaneous abortions and without other clinical features. Clinical, hematological, biochemical, and endocrinological aspects of the couple did not reveal any abnormalities. The karyotype of the wife was normal (46,XX), while the husband was found to have an abnormal karyotype, 47,XY,+der(22)mat. The marker chromosome was familial and non-satellite.

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