Spinal cord injury

Tetradecyl 2,3-dihydroxybenzoate promotes functional recovery after spinal cord injury in adult rats

Y. M. Ding, Zhu, J. Y., Zhang, S. J., Zhang, S. S., Wang, C., Wang, L. L., Zhang, X., Ding, Y. M., Zhu, J. Y., Zhang, S. J., Zhang, S. S., Wang, C., Wang, L. L., and Zhang, X., Tetradecyl 2,3-dihydroxybenzoate promotes functional recovery after spinal cord injury in adult rats, vol. 15, p. -, 2016.

Tetradecyl 2,3-dihydroxybenzoate (ABG001) is a small molecule separated from gentian extract that has a similar effect to nerve growth factor. It is not clear whether it can promote functional recovery in animals suffering from a central nervous system injury. In order to explore the role of ABG001 in restoration of tissue structure and motor function of rats with spinal cord injury (SCI), ABG001 (0.4 mg/kg) was administered intraperitoneally.

Alleviation of spinal cord injury by Ginkgolide B via the inhibition of STAT1 expression

J. L. Zheng, Li, B. S., Cao, X. C., Zhuo, W. K., Zhang, G., Zheng, J. L., Li, B. S., Cao, X. C., Zhuo, W. K., and Zhang, G., Alleviation of spinal cord injury by Ginkgolide B via the inhibition of STAT1 expression, vol. 15, p. -, 2016.

Ginkgolide B has been known to inhibit cell apoptosis by modulating multiple cytokines and plays an important role in neuroprotection. Signal transducer and activator of transcription 1 (STAT1) has been studied in a spinal cord injury (SCI) model. However, the role of Ginkgolide B in SCI treatment remains unclear. This study investigated the potential mechanism of Ginkgolide B using an SCI rat model. SD rats were used to generate an SCI model followed by Ginkgolide B injection (4 mg/kg) for 14 days.

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