Spinal cord injury

Effects of musk ketone on nerve recovery after spinal cord injury

L. Guo, Quan, Z. X., Zhao, Z. H., Tang, K., Ou, Y. S., and Jiang, D. M., Effects of musk ketone on nerve recovery after spinal cord injury, vol. 14, pp. 2958-2963, 2015.

The present study aimed to determine the effects of musk ketone on nerve recovery in rats after spinal cord injury. A total of 105 SD female rats were used to establish the rat with dorsal spinal cord injury model (modified Allen’s method). The rats weighed from 200 to 250 g and were provided by the Experimental Animal Center of Chongqing Medical University. They were randomly divided into five treatment groups: saline (NS group), methylprednisolone (MP group), and musk ketone groups (MO1, MO2, and MO3 groups).

Effect of lentivirus-mediated RNA interference of APC-Cdh1 expression on spinal cord injury in rats

Y. - H. Qi, Yao, W. - L., Zhang, C. - H., and Guo, Y. - Q., Effect of lentivirus-mediated RNA interference of APC-Cdh1 expression on spinal cord injury in rats, vol. 13, pp. 1366-1372, 2014.

This study investigated cadherin-1 (Cdh1) expression in the sensorimotor cortex of rats after spinal cord injury (SCI). The repairing effect of Cdh1 was evaluated by silencing its expression with lentivirus-mediated RNAi. Twenty male Sprague-Dawley (SD) rats were randomly divided into a normal group and an operation group. Rats of the operation group were given SCI by the Allen method (T10-T11). Cdh1 expression in the sensorimotor cortex was examined by quantitative real-time polymerase chain reaction (PCR) and Western blot analysis.

Effectiveness of olfactory ensheathing cell transplantation for treatment of spinal cord injury

Y. J. Rao, Zhu, W. X., Du, Z. Q., Jia, C. X., Du, T. X., Zhao, Q. A., Cao, X. Y., and Wang, Y. J., Effectiveness of olfactory ensheathing cell transplantation for treatment of spinal cord injury, vol. 13, pp. 4124-4129, 2014.

The aim of this study was to determine the effectiveness and safety of transplantation of olfactory ensheathing cells for functional repair of the spinal cord. An olfactory bulb was obtained from a 4- to 5-month-old aborted fetus, and it was digested into single olfactory ensheathing cells and then cultured and purified for 1 to 2 weeks. Under general anesthesia, these single-cell suspensions of olfactory ensheathing cells were injected into the corresponding spinal injury site with 0.45-mm-diameter injections.

Subscribe to Spinal cord injury