Spinal cord

Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors

B. X. Ren, Ji, Y., Tang, J. C., Sun, D. P., Hui, X., Yang, D. Q., and Zhu, X. L., “Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors”, vol. 14, pp. 2133-2138, 2015.

The study aimed to investigate the effect of intrathecal injections of Tanshinone IIA on thermal hyperalgesia in a mouse model of bone cancer-pain. Spinal IL-1β, IL-6, TNF-α expression levels were analyzed. C3H/HeNCrlVr male mice were assigned to groups that either received dose-dependent injections of Tanshinone IIA, or the DMSO + Sham, Tanshinone IIA + Sham, DMSO + Tumor, and Control groups. Paw withdrawal thermal latency (PWTL) was measured with a radiant heat stimulus and mRNA expression levels were determined using real-time PCR.

The noggin2 gene of Gekko japonicus (Gekkonidae) is down-regulated in the spinal cord after tail amputation

Y. Liu, Zhou, Y. L., Qian, Y. Y., Wang, Y. J., Ding, F., Gu, X. S., and Liu, M., “The noggin2 gene of Gekko japonicus (Gekkonidae) is down-regulated in the spinal cord after tail amputation”, vol. 9, pp. 1606-1614, 2010.

The cDNA encoding noggin2 protein was obtained from the brain and spinal cord cDNA library of Gekko japonicus. The size of the noggin2 transcript and its expression in different tissues were analyzed by Northern blot analysis. In situ hybridization revealed positive hybridization signals in both gray and white matter of the spinal cord. Changes in noggin2 expression in the spinal cord after tail amputation were examined by real-time PCR.

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