Spermatogenic failure

Copy number variations in spermatogenic failure patients with chromosomal abnormalities and unexplained azoospermia

Y. Dong, Pan, Y., Wang, R., Zhang, Z., Xi, Q., and Liu, R. - Z., Copy number variations in spermatogenic failure patients with chromosomal abnormalities and unexplained azoospermia, vol. 14, pp. 16041-16049, 2015.

Male infertility is mostly caused by spermatogenic failure. Currently, routine genetic analyses of unexplained azoospermia or oligozoospermia are limited to the investigation of Y chromosomal microdeletions and chromosome karyotype analyses. The aim of this study was to find spermatogenic failure genes in patients with chromosomal abnormalities and unexplained azoospermia caused by copy number variations in order to provide a theoretical basis for further research.

Sperm retrieval from patients with nonmosaic Klinefelter’s syndrome by semen cytology examination

Y. - T. Jiang, Dong, Y., Yu, X. - W., Du, R. - C., Li, L. - L., Zhang, H. - G., and Liu, R. - Z., Sperm retrieval from patients with nonmosaic Klinefelter’s syndrome by semen cytology examination, vol. 13, pp. 1848-1854, 2014.

Successful sperm retrieval from ejaculates of nonmosaic Klinefelter’s syndrome (KS) patients by using semen cytology examination was described in this report. The clinical parameters of KS patients with sperm compared to patients without sperm were described. One hundred and fifty-one patients were proven to suffer from KS by chromosomal analysis using G-banding. Spermatozoa were obtained from 10 patients (10/151, 6.6%) using semen analysis. After semen cytology examination, 32 patients (32/151, 21.2%) were found to have sperm or germ cell in their ejaculate.

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