Somatic cell score

Genetic polymorphisms of the BMAP-28 and MASP-2 genes and their correlation with the somatic cell score in Chinese Holstein cattle

J. Wu, Bai, J. Y., Li, L., Huang, S., Li, C. M., and Wang, G. L., Genetic polymorphisms of the BMAP-28 and MASP-2 genes and their correlation with the somatic cell score in Chinese Holstein cattle, vol. 14, pp. 1-8, 2015.

DNA sequencing, nested polymerase chain reaction (PCR), and PCR-restriction fragment length polymorphism were used to investigate mutations in the coding regions of the bovine myeloid antimicrobial peptide-28 (BMAP-28) and mannan-binding lectin-associated serine protease-2 (MASP-2) genes in 249 Chinese Holstein dairy cows. The associations between the polymorphisms and somatic cell score (SCS) were analyzed to determine the potential of these genes as genetic markers for breeding mastitis-resistant dairy cattle.

Polymorphisms of the ATP1A1 gene associated with mastitis in dairy cattle

Y. X. Liu, Xu, C. H., Gao, T. Y., and Sun, Y., Polymorphisms of the ATP1A1 gene associated with mastitis in dairy cattle, vol. 11, pp. 651-660, 2012.

Mastitis affects the concentrations of potassium and sodium in milk. Since sodium-potassium adenosine triphosphatase (Na+, K+-ATPase) is critical for maintaining the homeostasis of these two ions, and is involved in cell apoptosis and pathogenesis, we presumed that polymorphism of the ATP1A1 gene, which encodes the bovine Na+, K+-ATPase α1 subunit could be associated with mastitis.

Novel SNPs of the mannan-binding lectin 2 gene and their association with production traits in Chinese Holsteins

Z. L. Zhao, Wang, C. F., Li, Q. L., Ju, Z. H., Huang, J. M., Li, J. B., Zhong, J. F., and Zhang, J. B., Novel SNPs of the mannan-binding lectin 2 gene and their association with production traits in Chinese Holsteins, vol. 11, pp. 3744-3754, 2012.

The mannan-binding lectin gene (MBL) participates as an opsonin in the innate immune system of mammals, and single nucleotide polymorphisms (SNPs) in MBL cause various immune dysfunctions. In this study, we detected SNPs in MBL2 at exon 1 using polymerase chain reaction single-strand conformation polymorphism analysis and DNA sequencing techniques in 825 Chinese Holstein cows. Four new SNPs with various allele frequencies were also found. The g.1164 G>A SNP was predicted to substitute arginine with glutamine at the N-terminus of the cysteine-rich domain.

Impact of bovine somatotropin on ranking for genetic value of dairy sires for milk yield traits and somatic cell score

A. Al-Seaf, Keown, J. F., and Van Vleck, L. D., Impact of bovine somatotropin on ranking for genetic value of dairy sires for milk yield traits and somatic cell score, vol. 6, pp. 79-93, 2007.

Records of Holstein cows were used to examine how different models account for the effect of bovine somatotropin (bST) treatment on genetic evaluation of dairy sires for yield traits and somatic cell score. Data set 1 included 65,720 first-lactation records. Set 2 included 50,644 second-lactation records. Set 3 included 45,505 records for lactations three, four and five. Estimated breeding values (EBV) of sires were with three different animal models. With Model 1, bST administration was ignored. With Model 2, bST administration was used as a fixed effect.

Estimates of correlations among yield traits and somatic cell score with different models to adjust for bovine somatotropin effects on Holstein dairy cows

A. Al-Seaf, Keown, J. F., and Van Vleck, L. D., Estimates of correlations among yield traits and somatic cell score with different models to adjust for bovine somatotropin effects on Holstein dairy cows, vol. 6, pp. 67-78, 2007.

Records of Holstein cows from the Dairy Records Processing Center at Raleigh, NC were edited to obtain three data sets: 65,720 first, 50,694 second, and 65,445 later lactations. Correlations among yield traits and somatic cell score were estimated with three different models: 1) bovine somatotropin (bST) administration ignored, 2) bST administration as a fixed effect and 3) administration of bST as part of the contemporary group (herd-year-month-bST).

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