SNPs

Novel single nucleotide polymorphisms in the 5' regulatory region of the duck SCD1 gene and their associations with serum biochemical levels and fatty acid composition

W. - G. Li, Zhang, Y. - Y., Wang, D. - D., Li, W. - G., Zhang, Y. - Y., and Wang, D. - D., Novel single nucleotide polymorphisms in the 5' regulatory region of the duck SCD1 gene and their associations with serum biochemical levels and fatty acid composition, vol. 15, p. -, 2016.

Stearoyl-coenzyme A desaturase 1 (SCD1) is the key limiting enzyme in the synthesis of monounsaturated fatty acids, and plays a crucial role in the regulation of oleic acid. In this study, 165 ten-week-old Cherry Valley ducks were used to investigate single nucleotide polymorphisms (SNPs) in the 5' regulatory region of the SCD1 gene, and their associations with duck serum biochemical levels and fatty acid composition.

Haplo-block structure of Southern African village chicken populations inferred using genome-wide SNP data

K. S. Khanyile, Dzomba, E. F., and Muchadeyi, F. C., Haplo-block structure of Southern African village chicken populations inferred using genome-wide SNP data, vol. 14, pp. 12276-12287, 2015.

This study investigated the haplo-block structure, haplotype sharing, and diversity in extensively raised chicken populations of Southern Africa. Two hundred ninety village chickens from Malawi (N = 30), South Africa (N = 132), and Zimbabwe (N = 128) were included in the study, from which 649, 2104, and 2442 haplo-blocks were observed, respectively. The majority of haplo-blocks were smaller than 25 kb in size and only five blocks were more than 2000 kb in size.

Association of adiponectin gene polymorphisms with hypertensive disorder complicating pregnancy and disorders of lipid metabolism

Y. Wang, Liu, R. X., and Liu, H., Association of adiponectin gene polymorphisms with hypertensive disorder complicating pregnancy and disorders of lipid metabolism, vol. 14, pp. 15213-15223, 2015.

The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) in APM1 contribute to disorders of lipid metabolism in hypertensive disorder complicating pregnancy (HDCP). The study included 178 pregnant women with HDCP and 243 healthy pregnant controls. Using PCR-restriction fragment length polymorphism, we detected the frequencies of genotypes, alleles, and haplotypes of two SNPs, +45T>G (rs2241766) and +276G>T (rs1501299), in APM1.

Linkage analysis of SNPs in IGFBP-6 and its relation with the body sizes of pig

X. B. Fang, Liu, S. C., Wu, Q. Y., Li, S. M., Cheng, Y. Y., Fu, H. Y., Lu, C., Su, D., Yu, H., and Hao, L. L., Linkage analysis of SNPs in IGFBP-6 and its relation with the body sizes of pig, vol. 14, pp. 17273-17280, 2015.

Insulin-like growth factor binding protein-6 (IGFBP-6) is a member of the IGFBP family, which is known to be a key factor in regulating the effect of insulin-like growth factor-2 (IGF-2) on the animal growth and development. Gene sequences of 3'-untranslated regions (UTR) and exon 4 of IGFBP-6 may influence the expression and proteolysis of IGFBP-6.

Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia

S. - Q. Ge, Grifin, J., Liu, L. - H., Aston, K. I., Simon, L., Jenkins, T. G., Emery, B. R., and Carrell, D. T., Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia, vol. 14, pp. 9053-9061, 2015.

Male infertility is often associated with a decreased sperm count. The Pygo2 gene is expressed in the elongating spermatid during chromatin remodeling; thus impairment in PYGO2 function might lead to spermatogenic arrest, sperm count reduction, and subsequent infertility. The aim of this study was to identify mutations in Pygo2 that might lead to idiopathic oligospermia and azoospermia. DNA was isolated from venous blood from 77 men with normal fertility and 195 men with idiopathic oligospermia or azoospermia.

Comparison of methods used to identify superior individuals in genomic selection in plant breeding

L. L. Bhering, Junqueira, V. S., Peixoto, L. A., Cruz, C. D., and Laviola, B. G., Comparison of methods used to identify superior individuals in genomic selection in plant breeding, vol. 14, pp. 10888-10896, 2015.

The aim of this study was to evaluate different methods used in genomic selection, and to verify those that select a higher proportion of individuals with superior genotypes. Thus, F2 populations of different sizes were simulated (100, 200, 500, and 1000 individuals) with 10 replications each. These consisted of 10 linkage groups (LG) of 100 cM each, containing 100 equally spaced markers per linkage group, of which 200 controlled the characteristics, defined as the 20 initials of each LG.

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