SNP

A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil

A. V. C. Coelho, Moura, R. R., Cavalcanti, C. A. J., Guimarães, R. L., Sandrin-Garcia, P., Crovella, S., and Brandão, L. A. C., A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil, vol. 14, pp. 2876-2884, 2015.

Genetic association studies determine how genes influence traits. However, non-detected population substructure may bias the analysis, resulting in spurious results. One method to detect substructure is to genotype ancestry informative markers (AIMs) besides the candidate variants, quantifying how much ancestral populations contribute to the samples’ genetic background. The present study aimed to use a minimum quantity of markers, while retaining full potential to estimate ancestries.

Intracranial aneurysm risk factor genes: relationship with intracranial aneurysm risk in a Chinese Han population

L. T. Zhang, Wei, F. J., Zhao, Y., Zhang, Z., Dong, W. T., Jin, Z. N., Gao, F., Gao, N. N., Cai, X. W., Li, N. X., Wei, W., Xiao, F. S., Yue, S. Y., Zhang, J. N., Yang, S. Y., Li, W. D., and Yang, X. Y., Intracranial aneurysm risk factor genes: relationship with intracranial aneurysm risk in a Chinese Han population, vol. 14, pp. 6865-6878, 2015.

Few studies have examined the genes related to risk fac­tors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression models were used to analyze the association of IA and IA rup­ture with risk factors. Twenty-eight single nucleotide polymorphisms (SNPs) in 22 genes were genotyped for the patient and control groups.

A single nucleotide polymorphism of the TNRC9 gene associated with breast cancer risk in Chinese Han women

F. Chen, Zhou, J., Xue, Y., Yang, S., Xiong, M., Li, Y., and Liu, Q., A single nucleotide polymorphism of the TNRC9 gene associated with breast cancer risk in Chinese Han women, vol. 13, pp. 182-187, 2014.

A single nucleotide polymorphism (SNP) in the TNRC9 gene was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry. We investigated whether TNRC9 polymorphisms are associated with risk of breast cancer in Chinese women of the Han nationality. We genotyped the SNPs rs3803662, rs1362548, rs1123428 in 870 women, including 388 breast cancer patients and 482 healthy controls, via the PCR-single strand conformation polymorphism procedure and by sequence detection.

Polymorphism analysis of IGFBP-5 gene exon 1 in Tibet Mini-pig and Junmu No. 1 White pig

A. D. Chen, Hao, L. L., Fang, X. B., Lu, K., Liu, S. C., and Zhang, Y. L., Polymorphism analysis of IGFBP-5 gene exon 1 in Tibet Mini-pig and Junmu No. 1 White pig, vol. 13. pp. 1643-1649, 2014.

The genetic resources and the mechanism of miniaturization in the Tibet Mini-pig have not been comprehensively studied. Polymorphisms in genes related to the insulin-like growth factor (IGF) axis have been investigated for years, but few on the polymorphism of IGF-binding protein-5 (IGFBP-5) in the Tibetan pig. In this study, allele-specific polymerase chain reaction (AS-PCR) was used to analyze polymorphisms in exon 1 of the IGFBP-5 gene in two pig breeds, Tibet Mini-pigs and Junmu No. 1 White pigs.

Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese

Y. Zhao, Ding, M., Pang, H., Xu, X. M., and Wang, B. J., Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese, vol. 13, pp. 1609-1618, 2014.

Dopamine (DA) has been implicated in the pathophysiol­ogy of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopa­mine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs) in the regulatory regions of DRD5 gene may affect gene expression, influence biosynthesis of DA and underlie various neuropsychiatric disorders re­lated to DA dysfunction.

TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese

X. M. Xu, Ding, M., Pang, H., and Wang, B. J., TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese, vol. 13, pp. 1497-1507, 2014.

In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nucleotide polymorphisms (SNPs) in the regulatory regions of TPH2 gene may affect gene expression and biosynthesis of 5-HT triggering to various neuropsychiatric disorders related to 5-HT dysfunction.

Identification and characterization of RFRP gene in pigs and its association with reproductive traits

M. X. Fang, Huang, Y. S., Ye, J., Zhang, W., Li, Y., and Nie, Q. H., Identification and characterization of RFRP gene in pigs and its association with reproductive traits, vol. 13, pp. 1661-1671, 2014.

RFamide-related peptide (RFRP) gene is a crucial gene of the hypothalamo-pituitary-gonadal axis and plays an important role in reproduction regulation. This study aimed to clone and characterize the pig RFRP gene. We obtained a 645-bp cDNA of pig RFRP gene comprising a 546-bp open reading frame, which encoded a peptide of 188 amino acids. The pig RFRP coding sequences have the identities of 81, 68.8, and 76.1% with their counterparts in humans, mice, and rats, respectively.

Polymorphisms of PRLR and FOLR1 genes and association with milk production traits in goats

J. X. Hou, Fang, F., An, X. P., Yan, Y., Ma, T., Han, P., Meng, F. X., Song, Y. X., Wang, J. G., and Cao, B. Y., Polymorphisms of PRLR and FOLR1 genes and association with milk production traits in goats, vol. 13, pp. 2555-2562, 2014.

We investigated the polymorphisms of PRLR and FOLR1 genes in Xinong Saanen, Guanzhong, and Boer goat breeds by DNA sequencing and PCR–RFLP. Two novel SNPs were identified: KC109741: g.62130C>T in the 3ꞌ-UTR of goat gene PRLR, and KC136296: g.7884A>C in exon 3 of goat gene FOLR1. In the three goat breeds, the polymorphism information content was 0.20-0.27 at the g.62130C>T locus. At the g.7884A>C locus, it was 0.36 in Boer goats.

Association study of polymorphisms between the Radixin gene and rheumatoid arthritis in a Korean population

H. - K. Kim, Joo, J. - S., Lee, H. - Y., Kwon, J. - T., Sohn, D. - R., Hong, S. - J., and Kim, H. - J., Association study of polymorphisms between the Radixin gene and rheumatoid arthritis in a Korean population, vol. 13, pp. 3697-3703, 2014.

Radixin (RDX) is part of the ezrin-radixin-moesin (ERM) protein family. It functions as a membrane-cytoskeletal linker in actin-rich cell surface structures and is thought to be essential for cortical cytoskeleton organization, cell motility, adhesion, and proliferation. An increase in phosphorylated ERM in fibroblast-like synoviocytes contributes to rheumatoid arthritis (RA) synovial hyperplasia. We examined the genetic association between the RDX gene and RA in a Korean population.

Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese women

H. Lin, Yin, Z., Yu, X. Y., Lin, N., Lin, Y., Chen, J., Chen, Y. Z., Lu, K. P., and Liu, H. K., Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese women, vol. 13, pp. 6126-6134, 2014.

We examined the influence of the promoter polymorphisms -250G/A (rs2070895) and -514C/T (rs1800588) in the human hepatic lipase (LIPC) gene on dyslipidemia and hypertensive disorders complicating pregnancy (HDCP) in a Chinese population. Clinically defined HDCP patients (N = 321) and healthy pregnant women (N = 331) were recruited and genotyped using polymerase chain reaction-restriction fragment length polymorphism for the two LIPC single nucleotide polymorphisms (SNPs).

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