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Intracranial aneurysm risk factor genes: relationship with intracranial aneurysm risk in a Chinese Han population

L. T. Zhang, Wei, F. J., Zhao, Y., Zhang, Z., Dong, W. T., Jin, Z. N., Gao, F., Gao, N. N., Cai, X. W., Li, N. X., Wei, W., Xiao, F. S., Yue, S. Y., Zhang, J. N., Yang, S. Y., Li, W. D., and Yang, X. Y., “Intracranial aneurysm risk factor genes: relationship with intracranial aneurysm risk in a Chinese Han population”, vol. 14, pp. 6865-6878, 2015.

Few studies have examined the genes related to risk fac­tors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression models were used to analyze the association of IA and IA rup­ture with risk factors. Twenty-eight single nucleotide polymorphisms (SNPs) in 22 genes were genotyped for the patient and control groups.

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