SNP

Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese

Y. Zhao, Ding, M., Pang, H., Xu, X. M., and Wang, B. J., Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese, vol. 13, pp. 1609-1618, 2014.

Dopamine (DA) has been implicated in the pathophysiol­ogy of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopa­mine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs) in the regulatory regions of DRD5 gene may affect gene expression, influence biosynthesis of DA and underlie various neuropsychiatric disorders re­lated to DA dysfunction.

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